Platelet Rich Fibrin (PRF)
Experience the next evolution in regenerative aesthetics with Platelet Rich Fibrin at Advanced Skin MedSpa in Fishkill, NY. PRF harnesses a denser, slower-releasing matrix of your own growth factors for longer-lasting rejuvenation of the skin, under-eyes, and hair — no synthetic fillers, no chemicals, just your body's natural healing power.
What Is PRF and How Is It Different from PRP?
Platelet Rich Fibrin (PRF) is a second-generation regenerative concentrate derived from your own blood, similar to PRP but with key advancements that make it even more effective for aesthetic applications. Like PRP, the process begins with a simple blood draw. However, PRF is processed at a lower centrifuge speed, which preserves a greater concentration of white blood cells, stem cells, and platelets within a natural fibrin matrix.
This fibrin scaffold is what sets PRF apart. Rather than releasing growth factors in a single burst the way PRP does, the fibrin matrix acts as a slow-release delivery system, gradually dispersing growth factors over seven to ten days. This extended release promotes more sustained collagen stimulation, tissue regeneration, and cellular repair. Because PRF uses no anticoagulants or additives in processing, the result is a 100% natural, autologous product that your body recognizes and accepts completely.
PRF Treatment Applications
Under-Eye Rejuvenation: PRF is one of the most effective natural treatments for dark circles, hollowing, and crepey skin under the eyes. The fibrin matrix integrates into the delicate under-eye tissue, thickening the skin and improving tone over several weeks. Many patients prefer PRF here because it avoids the risks of synthetic filler migration in this sensitive area.
Full Facial Rejuvenation: Injected into the cheeks, temples, nasolabial folds, and jawline, PRF stimulates your body's own collagen production for gradual, natural-looking volume and texture improvement. Results develop over two to three months as new collagen forms around the fibrin scaffold.
Hair Restoration: PRF injections into the scalp deliver concentrated growth factors directly to thinning hair follicles. The slow-release fibrin matrix provides prolonged stimulation, encouraging follicles to re-enter the active growth phase and produce thicker, stronger hair.
Skin Quality Enhancement: PRF can be combined with microneedling to dramatically improve skin texture, pore size, acne scarring, and overall radiance. The microneedling channels allow the PRF to penetrate deeper for amplified results.
What to Expect During Your PRF Session
Your PRF treatment at Advanced Skin MedSpa begins with a small blood draw, typically two to four tubes depending on the treatment area. The blood is placed in a specialized centrifuge that spins at a carefully calibrated low speed to produce the fibrin-rich concentrate while preserving the maximum number of regenerative cells.
Once the PRF is prepared, it is injected using fine needles into the targeted treatment areas. For facial rejuvenation, the injections are placed at strategic depths to stimulate collagen where it matters most. The entire process from blood draw to completion typically takes 30 to 45 minutes.
There is minimal downtime after PRF treatment. You may experience mild swelling, tenderness, or bruising at the injection sites for two to five days, particularly in the under-eye area. Results develop gradually over the following weeks as the fibrin matrix releases growth factors and new collagen forms. Most patients see optimal results after a series of three treatments spaced four to six weeks apart, with maintenance sessions every six to twelve months.
Why Choose PRF
Slow-Release Growth Factors
The fibrin matrix releases growth factors over 7–10 days for more sustained collagen stimulation than a single PRP burst.
100% Natural & Autologous
Made entirely from your own blood with no additives, anticoagulants, or synthetic materials — zero risk of allergic reaction.
Ideal for Under-Eyes
Safely treats the delicate under-eye area where synthetic fillers carry migration risks — a natural alternative for dark circles and hollowing.
Higher Cell Concentration
Lower-speed processing preserves more white blood cells and stem cells than traditional PRP for enhanced regeneration.
Versatile Applications
Effective for facial rejuvenation, under-eyes, hair restoration, and skin quality when combined with microneedling.
Minimal Downtime
Quick 30–45 minute sessions with only mild swelling for a few days — results build naturally over weeks.
Frequently Asked Questions
Both are derived from your own blood, but PRF is processed at a lower centrifuge speed that preserves a fibrin matrix along with a higher concentration of white blood cells and stem cells. This fibrin scaffold releases growth factors gradually over 7–10 days rather than all at once, providing more sustained stimulation for collagen production and tissue regeneration.
Most patients achieve optimal results with a series of three treatments spaced four to six weeks apart. For hair restoration, we may recommend additional sessions. After your initial series, maintenance treatments every six to twelve months help sustain your results long-term.
Yes. PRF is one of the safest options for under-eye rejuvenation because it is entirely derived from your own body and integrates naturally into the tissue. Unlike synthetic fillers, there is no risk of product migration, lumping, or Tyndall effect (bluish discoloration) in this delicate area.
PRF results develop gradually as your body builds new collagen around the fibrin scaffold. Most patients notice initial improvement within two to three weeks, with results continuing to improve over two to three months. The natural, progressive nature of the results means changes look authentic rather than sudden.
The blood draw is similar to routine lab work and takes just a few minutes. Most patients find it very manageable. For the injection portion, we can apply topical numbing cream to the treatment area for added comfort.
Absolutely. PRF pairs exceptionally well with microneedling for enhanced skin texture and scar revision. It can also complement neurotoxin and filler treatments as part of a comprehensive rejuvenation plan. Your provider will recommend the ideal combination based on your goals.